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Results After four years, the risk of recurrent stroke was 2. Airfoil Keygen Crack Serials. 3 percent (95 percent confidence interval, 0.3 to 4.3 percent) among the patients with patent foramen ovale alone, 15.2 percent (95 percent confidence interval, 1.8 to 28.6 percent) among the patients with both patent foramen ovale and atrial septal aneurysm, and 4.2 percent (95 percent confidence interval, 1.8 to 6.6 percent) among the patients with neither of these cardiac abnormalities. There were no recurrences among the patients with an atrial septal aneurysm alone. The presence of both cardiac abnormalities was a significant predictor of an increased risk of recurrent stroke (hazard ratio for the comparison with the absence of these abnormalities, 4.17; 95 percent confidence interval, 1.47 to 11.84), whereas isolated patent foramen ovale, whether small or large, was not.

During the past 15 years, the potential role of patent foramen ovale and atrial septal aneurysm in the genesis of ischemic stroke in young adults has been investigated. In addition to uncertainty about the mechanisms of stroke, therapeutic decisions are hindered by the lack of precise data on the risk of recurrent stroke. The few studies of this topic were retrospective, did not include a control group of patients with neither of these septal abnormalities, involved small numbers of patients, or used heterogeneous treatments for secondary prevention. In addition, the variability in the diagnosis of these septal abnormalities was usually not taken into account. This follow-up study was designed to assess the absolute and relative risks of recurrent cerebrovascular events associated with these septal disorders in young patients with an otherwise unexplained ischemic stroke who were receiving aspirin and to identify subgroups of patients with a high risk of recurrent stroke. Methods Patients were consecutively enrolled at 30 neurology departments in Europe between May 1, 1996, and December 31, 1998, and were followed until December 31, 2000. Eligible patients were 18 to 55 years of age and had had an ischemic stroke (defined as a neurologic deficit that lasted more than 24 hours) within the preceding three months for which no definite cause had been identified after a standardized workup.