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Adobe Flash Player is required to view this feature. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Original Article A Controlled Trial of Arthroscopic Surgery for Osteoarthritis of the Knee J. Bruce Moseley, M.D., Kimberly O'Malley, Ph.D., Nancy J.

Petersen, Ph.D., Terri J. Menke, Ph.D., Baruch A. Brody, Ph.D., David H. Kuykendall, Ph.D., John C. Hollingsworth, Dr.P.H., Carol M. Ashton, M.D., M.P.H., and Nelda P. Wray, M.D., M.P.H.

N Engl J Med 2002; 347:81-88 DOI: 10.1056/NEJMoa013259. The Dame Was Loaded Isolation more. Study Participants Participants were recruited from the Houston Veterans Affairs Medical Center from October 1995 through September 1998. Patients were eligible if they were 75 years old or younger, had osteoarthritis of the knee as defined by the American College of Rheumatology, reported at least moderate knee pain on average (≥4 on a visual-analogue scale ranging from 0 to 10) despite maximal medical treatment for at least six months, and had not undergone arthroscopy of the knee during the previous two years. The severity of osteoarthritis in the study knee (that with the greatest pain-induced limitation of function) was assessed radiographically and graded on a scale of zero to four. The scores for the three compartments were added together to generate a severity grade of 0 to 12. Criteria for exclusion were a severity grade of 9 or higher, severe deformity, and serious medical problems. All patients provided informed consent, which included writing in their chart, “On entering this study, I realize that I may receive only placebo surgery.

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